Yeranuhi Karakachian first took the stage at the age of 16 in the play King Tiridat (Büyük Drtad) at the Eastern Theatre in Constantinople during the 1864-65 season, under the direction of Sirabiyon Hekimyan. Later, she began to perform at the Aziziye Theatre in Üsküdar.
When she was 17 years of age, theatre critics such as Hagop Baronyan wrote rave reviews of her work in the press. At the beginning of her career, she took on the roles of young men, such as Paul in Paul and Virginia, Ata in The Poor Child, and Osep in Beautiful Osep.
